p53 sends nucleotides to repair DNA
نویسندگان
چکیده
منابع مشابه
Postprandial Activation of P53-Dependent DNA Repair
Background. Alterations in the expression levels of genes and proteins involved in oxidative stress and DNA damage response underlie the phenotypic changes associated with aging. We have investigated whether the quality of dietary fat alters postprandial gene expression and protein levels involved in p53-dependent DNA repair and whether the supplementation with Coenzyme Q 10 improves this situa...
متن کاملp53 downregulates the Fanconi anaemia DNA repair pathway
Germline mutations affecting telomere maintenance or DNA repair may, respectively, cause dyskeratosis congenita or Fanconi anaemia, two clinically related bone marrow failure syndromes. Mice expressing p53(Δ31), a mutant p53 lacking the C terminus, model dyskeratosis congenita. Accordingly, the increased p53 activity in p53(Δ31/Δ31) fibroblasts correlated with a decreased expression of 4 genes ...
متن کاملA p53 Oscillator Model of DNA Break Repair Control
The transcription factor p53 is an important regulator of cell fate. Mutations in p53 gene are associated with many cancers. In response to signals such as DNA damage, p53 controls the transcription of a series of genes that cause cell cycle arrest during which DNA damage is repaired, or triggers programmed cell death that eliminates possibly cancerous cells wherein DNA damage might have remain...
متن کاملDNA repair and aging: the impact of the p53 family.
Cells are constantly exposed to endogenous and exogenous factors that threaten the integrity of their DNA. The maintenance of genome stability is of paramount importance in the prevention of both cancer and aging processes. To deal with DNA damage, cells put into operation a sophisticated and coordinated mechanism, collectively known as DNA damage response (DDR). The DDR orchestrates different ...
متن کاملWVFI sends proposal to ND administrators
MANILA, Philippines President Ferdinand Marcos took an early lead over challenger Corazon Aquino yesterday in the official canvass by the National Assembly of last w eek’s presidential election. In a brief television appearance, Marcos pledged to "honor, w ithout reservations, the people's verdict at the polls and to ex tend our hand in conciliation to those w ho have co n tested the election...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature
سال: 2000
ISSN: 0028-0836,1476-4687
DOI: 10.1038/35003670